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  • Extrafollicular IgD plus B cells generate IgE antibody secreting cells in the nasal mucosa
  • An allosteric PGAM1 inhibitor effectively suppresses pancreatic ductal adenocarcinoma
  • Topologically associating domains are stable units of replication-timing regulation
  • Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia-TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial