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Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction, and cellular dNTP levels

Authors:Moritz Schüssler, Paul-Ehrlich-InstitutKerstin Schott, Paul-Ehrlich-InstitutNina verrena Fuchs, Paul-Ehrlich-InstitutAdrian Oo, Emory UniversityMorssal Zahadi, Paul-Ehrlich-Institutpaula Rauch, Paul-Ehrlich-InstitutBaek Kim, Emory UniversityRenate König, Paul-Ehrlich-Institut

Date:2023

Publisher:American Society for Microbiology

Publication Version:Final Published Version

License:Creative Commons Attribution 4.0 International

Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction and cellular dNTP levels

Authors:Moritz Schüssler, Paul-Ehrlich-InstitutKerstin Schott, Paul-Ehrlich-InstitutNina Verena Fuchs, Paul-Ehrlich-InstitutAdrian Oo, Emory UniversityMorssal Zahadi, Paul-Ehrlich-InstitutPaula Rauch, Paul-Ehrlich-InstitutBaek Kim, Emory UniversityRenate König, Paul-Ehrlich-Institut

Date:2023

Publisher:NIH

Publication Version:Preprint (Prior to Peer Review)

License:Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International

Biochemical functions and structure of Caenorhabditis elegans ZK177.8 protein: Aicardi–Goutières syndrome SAMHD1 dNTPase ortholog

Authors:Tatsuya Maehigashi, Emory UniversityChristopher Lim, Yale UniversityLydia R. Wade, Emory UniversityNicole E. Bowen, Emory UniversityKirsten M. Knecht, Yale UniversityNatalie Alvarez, Emory UniversityWilliam G Kelly, Emory UniversityRaymond F Schinazi, Emory UniversityDong-Hyun Kim, Kyung-Hee UniversityYong Xiong, Yale UniversityBaek Kim, Emory University

Date:2023

Publisher:American Society for Biochemistry and Molecular Biology

Publication Version:Final Published Version

License:Creative Commons Attribution 4.0 International

Vpx requires active cellular dNTP biosynthesis to effectively counteract the anti-lentivirus activity of SAMHD1 in macrophages

Authors:Nicole E Bowen, Emory UniversitySijia Tao, Emory UniversityYoung-Jae Cho, Emory UniversityRaymond Schinazi, Emory UniversityBaek Kim, Emory University

Date:2023

Publisher:Elsevier Inc

Publication Version:Final Published Version

License:Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International

Targeting SAMHD1 with hydroxyurea in first-line cytarabine-based therapy of newly diagnosed acute myeloid leukaemia: Results from the HEAT-AML trial

Authors:Martin Jadersten, Karolinska University HospitalIngrid Lilienthal, Karolinska InstitutetNikolaos Tsesmetzis, Karolinska InstitutetMagda Lourda, Karolinska InstitutetSofia Bengtzen, Karolinska InstitutetAnna Bohlin, Karolinska InstitutetCorneila Arnroth, Karolinska InstitutetTom Erkers, Karolinska InstitutetBrinton Seashore-Ludlow, Karolinska InstitutetGéraldine Giraud, Uppsala UniversityGiti S Barkhordar, Sahlgrenska University HospitalSijia Tao, Emory UniversityLinda Fogelstrand, Sahlgrenska University HospitalLeonie Saft, Karolinska InstitutetPäivi Östling, Karolinska InstitutetRaymond Schinazi, Emory UniversityBaek Kim, Emory UniversityTorsten Schaller, University Hospital HeidelbergGunnar Juliusson, Skane University HospitalStefan Deneberg, Karolinska University HospitalSören Lehmann, Karolinska InstitutetGeorgios Z Rassidakis, Karolinska InstitutetMartin Höglund, Uppsala UniversityJan-Inge Henter, Karolinska InstitutetNikolas Herold, Karolinska Institutet

Date:2022

Publisher:WILEY

Publication Version:Final Published Version

License:Creative Commons Attribution-NonCommercial 4.0 International

Mechanistic Interplay between HIV-1 Reverse Transcriptase Enzyme Kinetics and Host SAMHD1 Protein: Viral Myeloid-Cell Tropism and Genomic Mutagenesis

Authors:Nicole E Bowen, Emory UniversityAdrian Oo, Emory UniversityBaek Kim, Emory University

Date:2022

Publisher:MDPI

Publication Version:Final Published Version

License:Creative Commons Attribution 4.0 International

The dNTPase activity of SAMHD1 is important for its suppression of innate immune responses in differentiated monocytic cells

Authors:Zhihua Qin, Ohio State UniversitySerena Bonifati, Ohio State UniversityCorine St Gelais, Ohio State UniversityTai-Wei Li, Ohio State UniversityJenna M. Antonucci, Ohio State UniversityBijan Mahboubi, Emory UniversityJacob S. Yount, Ohio State UniversityYong Xiong, Yale UniversityBaek Kim, Emory UniversityLi Wu, Ohio State University

Date:2020

Publisher:American Society for Biochemistry and Molecular Biology

Publication Version:Final Published Version

License:Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International

HIV-1 Uncoating and Nuclear Import Precede the Completion of Reverse Transcription in Cell Lines and in Primary Macrophages

Authors:Ashwanth Francis, Emory UniversityMariana Marin, Emory UniversityMathew J. Prellberg, Emory UniversityKristina Palermino-Rowland, Emory UniversityGregory Melikian, Emory University

Date:2020

Publisher:MDPI

Publication Version:Final Published Version

License:Creative Commons Attribution 4.0 International

Efficient pre-catalytic conformational change of reverse transcriptases from SAMHD1 non-counteracting primate lentiviruses during dNTP incorporation

Authors:Si'Ana Coggins, Emory UniversityJessica M. Holler, Emory UniversityJason T. Kimata, Baylor College of MedicineRaymond Schinazi, Emory UniversityBaek Kim, Emory University

Date:2019

Publisher:Academic Press Inc. Elsevier Science

Publication Version:Author Accepted Manuscript (After Peer Review)

License:Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International

HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains

Authors:Ashwanth Francis, Emory UniversityMariana Marin, Emory UniversityParmit K. Singh, Dana Farber Cancer InstituteVasudevan Achuthan, Dana Farber Cancer InstituteMathew J. Prellberg, Emory UniversityKristina Palermino-Rowland, Emory UniversityShuiyun Lan, Emory UniversityPhilip Tedbury, Emory UniversityStefan Sarafianos, Emory UniversityAlan Engelman, Dana Farber Cancer InstituteGregory Melikian, Emory University

Date:2020

Publisher:Nature Portfolio

Publication Version:Final Published Version

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