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  • The ability of SAMHD1 to block HIV-1 but not SIV requires expression of MxB

    The ability of SAMHD1 to block HIV-1 but not SIV requires expression of MxB
    Authors:Cindy Buffone, Albert Einstein College of MedicineJuliane Kutzner, University Hospital HeidelbergSilvana Opp, Albert Einstein College of MedicineAlicia Martinez-Lopez, Albert Einstein College of MedicineAnastasia Selyutina, Albert Einstein College of MedicineSi Ana Coggings, Emory UniversityLydia R. Studdard, Emory UniversityLingmei Ding, Cincinnati Children's HospitalBaek Kim, Emory UniversityPaul Spearman, Emory UniversityTorsten Schaller, University Hospital HeidelbergFelipe Diaz-Griffero, Albert Einstein College of Medicine
    Date:2019
    Publisher:Elsevier
    Publication Version:Author Accepted Manuscript (After Peer Review)
    License:Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International

  • Host SAMHD1 protein restricts endogenous reverse transcription of HIV-1 in nondividing macrophages

    Host SAMHD1 protein restricts endogenous reverse transcription of HIV-1 in nondividing macrophages
    Authors:Bijan Mahboubi, Emory UniversityChristina Gavegnano, Emory UniversityDong-Hyun Kim, Kyung-Hee UniversityRaymond Schinazi, Emory UniversityBaek Kim, Emory University
    Date:2018
    Publisher:BMC (part of Springer Nature)
    Publication Version:Final Published Version
    License:Creative Commons Attribution 4.0 International

  • The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation

    The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation
    Authors:Alexandra Herrmann, Friedrich-Alexander University Erlangen-NürnbergSabine Wittmann, Friedrich-Alexander University Erlangen-NürnbergDominique Thomas, Goethe-UniversityCaitlin Shepard, Emory UniversityBaek Kim, Emory UniversityNerea Ferreiros, Goethe-UniversityThomas Gramberg, Friedrich-Alexander University Erlangen-Nürnberg
    Date:2018
    Publisher:BMC (part of Springer Nature)
    Publication Version:Final Published Version
    License:Creative Commons Attribution 4.0 International

  • Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55 alpha holoenzymes during mitotic exit

    Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55 alpha holoenzymes during mitotic exit
    Authors:Kerstin Schott, Paul Ehrlich InstituteNina V. Fuchs, Paul Ehrlich InstituteRita Derua, Katholieke Universiteit LeuvenBijan Mahboubi, Emory UniversityEsther Schnellbaecher, Paul Ehrlich InstituteJanna Seifried, Paul Ehrlich InstituteChristiane Tondera, Paul Ehrlich InstituteHeike Schmitz, Paul Ehrlich InstituteCaitlin Shepard, Emory UniversityAlberto Brandariz-Nunez, Albert Einstein College of MedicineFelipe Diaz-Griffero, Albert Einstein College of MedicineAndreas Reuter, Paul Ehrlich InstituteBaek Kim, Emory UniversityVeerle Janssens, Katholieke Universiteit LeuvenRenate Koenig, Paul Ehrlich Institute
    Date:2018
    Publisher:Nature Publishing Group: Nature Communications
    Publication Version:Final Published Version
    License:Creative Commons Attribution 4.0 International

  • A SAMHD1 mutation associated with Aicardi-Goutieres syndrome uncouples the ability of SAMHD1 to restrict HIV-1 from its ability to downmodulate type I interferon in humans

    A SAMHD1 mutation associated with Aicardi-Goutieres syndrome uncouples the ability of SAMHD1 to restrict HIV-1 from its ability to downmodulate type I interferon in humans
    Authors:Tommy E. White, Albert Einstein College of Medicine BronxAlberto Brandariz-Nunez, Albert Einstein College of Medicine BronxAlicia Martinez-Lopez, Albert Einstein College of Medicine BronxCaitlin Knowlton, Emory UniversityGina Lenzi, Emory UniversityBaek Kim, Emory UniversityDmitri Ivanov, University of Texas Health Science CenterFelipe Diaz-Griffero, Albert Einstein College Medicine Bronx
    Date:2017
    Publisher:Wiley: 12 months
    Publication Version:Author Accepted Manuscript (After Peer Review)

  • Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle

    Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle
    Authors:Andreas F. Sommer, Paul-Ehrlich-InstituteLise Rivière, Paul-Ehrlich-InstituteBingqian Qu, University Hospital HeidelbergKerstin Schott, Paul-Ehrlich-InstituteMaximilian Riess, Paul-Ehrlich-InstituteYi Ni, University Hospital HeidelbergCaitlin Shepard, Emory UniversityEsther Schnellbaecher, Paul-Ehrlich-InstituteMalin Finkernagel, Paul-Ehrlich-InstituteKiyoshi Himmelsbach, Paul-Ehrlich-InstituteKarin Welzel, Paul-Ehrlich-InstituteNadja Kettern, Paul-Ehrlich-InstituteChristian Donnerhak, Paul-Ehrlich-InstituteCarsten Münk, Heinrich Heine University DüsseldorfEgbert Flory, Paul-Ehrlich-InstituteJuliane Liese, Goethe University FrankfurtBaek Kim, Emory UniversityStephan Urban, University Hospital HeidelbergRenate König, Paul-Ehrlich-Institute
    Date:2016
    Publisher:Nature Publishing Group
    Publication Version:Final Published Version
    License:Creative Commons Attribution 4.0 International