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Mechanistic Interplay between HIV-1 Reverse Transcriptase Enzyme Kinetics and Host SAMHD1 Protein: Viral Myeloid-Cell Tropism and Genomic Mutagenesis

Authors:Nicole E Bowen, Emory UniversityAdrian Oo, Emory UniversityBaek Kim, Emory University

Date:2022

Publisher:MDPI

Publication Version:Final Published Version

License:Creative Commons Attribution 4.0 International

SAMHD1 deficient human monocytes autonomously trigger type I interferon

Authors:Alicia Martinez-Lopez, Albert Einstein College of MedicineMarta Martin-Fernandez, Icahn School of Medicine at Mount SinaiSofija Buta, Icahn School of Medicine at Mount SinaiBaek Kim, Emory UniversityDusan Bogunovic, Icahn School of Medicine at Mount SinaiFelipe Diaz-Griffero, Albert Einstein College of Medicine

Date:2018

Publisher:Elsevier: 12 months

Publication Version:Author Accepted Manuscript (After Peer Review)

License:Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International

The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation

Authors:Alexandra Herrmann, Friedrich-Alexander University Erlangen-NürnbergSabine Wittmann, Friedrich-Alexander University Erlangen-NürnbergDominique Thomas, Goethe-UniversityCaitlin Shepard, Emory UniversityBaek Kim, Emory UniversityNerea Ferreiros, Goethe-UniversityThomas Gramberg, Friedrich-Alexander University Erlangen-Nürnberg

Date:2018

Publisher:BMC (part of Springer Nature)

Publication Version:Final Published Version

License:Creative Commons Attribution 4.0 International

Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55 alpha holoenzymes during mitotic exit

Authors:Kerstin Schott, Paul Ehrlich InstituteNina V. Fuchs, Paul Ehrlich InstituteRita Derua, Katholieke Universiteit LeuvenBijan Mahboubi, Emory UniversityEsther Schnellbaecher, Paul Ehrlich InstituteJanna Seifried, Paul Ehrlich InstituteChristiane Tondera, Paul Ehrlich InstituteHeike Schmitz, Paul Ehrlich InstituteCaitlin Shepard, Emory UniversityAlberto Brandariz-Nunez, Albert Einstein College of MedicineFelipe Diaz-Griffero, Albert Einstein College of MedicineAndreas Reuter, Paul Ehrlich InstituteBaek Kim, Emory UniversityVeerle Janssens, Katholieke Universiteit LeuvenRenate Koenig, Paul Ehrlich Institute

Date:2018

Publisher:Nature Publishing Group: Nature Communications

Publication Version:Final Published Version

License:Creative Commons Attribution 4.0 International

A SAMHD1 mutation associated with Aicardi-Goutieres syndrome uncouples the ability of SAMHD1 to restrict HIV-1 from its ability to downmodulate type I interferon in humans

Authors:Tommy E. White, Albert Einstein College of Medicine BronxAlberto Brandariz-Nunez, Albert Einstein College of Medicine BronxAlicia Martinez-Lopez, Albert Einstein College of Medicine BronxCaitlin Knowlton, Emory UniversityGina Lenzi, Emory UniversityBaek Kim, Emory UniversityDmitri Ivanov, University of Texas Health Science CenterFelipe Diaz-Griffero, Albert Einstein College Medicine Bronx

Date:2017

Publisher:Wiley: 12 months

Publication Version:Author Accepted Manuscript (After Peer Review)

A central role for PI3K-AKT signaling pathway in linking SAMHD1-deficiency to the type I interferon signature

Authors:Changhoon Oh, Seoul National UniversityJeongmin Ryoo, Seoul National UniversityKiwon Park, Seoul National UniversityBaek Kim, Emory UniversityMichele B. Daly, Emory UniversityDongYeon Cho, Seoul National UniversityKwangseog Ahn, Seoul National University

Date:2018

Publisher:Nature Publishing Group: Open Access Journals - Option C

Publication Version:Final Published Version

License:Creative Commons Attribution 4.0 International

SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination

Authors:Waaqo Daddacha, Emory UniversityAllyson E. Koyen, Emory UniversityAmanda J. Bastien, Emory UniversityPamela Sara E. Head, Emory UniversityVishal R. Dhere, Emory UniversityGeraldine N. Nabeta, Emory UniversityErin C. Connolly, Emory UniversityErica Werner, Emory UniversityMatthew Z. Madden, Emory UniversityMichele B. Daly, Emory University

Date:2017

Publisher:Elsevier (Cell Press): OAJ

Publication Version:Final Published Version

License:Creative Commons Attribution-NonCommerical-NoDerivs 3.0 Unported

Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle

Authors:Andreas F. Sommer, Paul-Ehrlich-InstituteLise Rivière, Paul-Ehrlich-InstituteBingqian Qu, University Hospital HeidelbergKerstin Schott, Paul-Ehrlich-InstituteMaximilian Riess, Paul-Ehrlich-InstituteYi Ni, University Hospital HeidelbergCaitlin Shepard, Emory UniversityEsther Schnellbaecher, Paul-Ehrlich-InstituteMalin Finkernagel, Paul-Ehrlich-InstituteKiyoshi Himmelsbach, Paul-Ehrlich-InstituteKarin Welzel, Paul-Ehrlich-InstituteNadja Kettern, Paul-Ehrlich-InstituteChristian Donnerhak, Paul-Ehrlich-InstituteCarsten Münk, Heinrich Heine University DüsseldorfEgbert Flory, Paul-Ehrlich-InstituteJuliane Liese, Goethe University FrankfurtBaek Kim, Emory UniversityStephan Urban, University Hospital HeidelbergRenate König, Paul-Ehrlich-Institute

Date:2016

Publisher:Nature Publishing Group

Publication Version:Final Published Version

License:Creative Commons Attribution 4.0 International

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